SYNTHESIS OF PEPTIDYL ACETALS AS INHIBITORS OF PROLYL ENDOPEPTIDASE

被引：12

作者：

AUGUSTYNS, K

BORLOO, M

BELYAEV, A

RAJAN, P

GOOSSENS, F

HENDRIKS, D

SCHARPE, S

HAEMERS, A

机构：

[1] UNIV INSTELLING ANTWERP, DEPT PHARMACEUT CHEM, B-2610 WILRIJK, BELGIUM

[2] UNIV INSTELLING ANTWERP, DEPT MED BIOCHEM, B-2610 WILRIJK, BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 12期

关键词：

D O I：

10.1016/0960-894X(95)00206-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several acyclic and cyclic dipeptidyl acetals were synthesized. Among these, N-[N-benzyloxycarbonyl-(S)-prolyl]-(S)-prolinal dimethyl acetal 8 was shown to be a potent inhibitor of prolyl endopeptidase.

引用

页码：1265 / 1270

页数：6

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