ABSORPTION-SPECTROSCOPY IN TISSUE-SIMULATING MATERIALS - A THEORETICAL AND EXPERIMENTAL-STUDY OF PHOTON PATHS

被引:126
作者
PATTERSON, MS
ANDERSSONENGELS, S
WILSON, BC
OSEI, EK
机构
[1] MCMASTER UNIV,HAMILTON,ON,CANADA
[2] LUND INST TECHNOL,LUND,SWEDEN
[3] ONTARIO CANC INST,TORONTO,ON,CANADA
[4] ONTARIO LASER & LIGHTWAVE RES CTR,TORONTO,ON,CANADA
来源
APPLIED OPTICS | 1995年 / 34卷 / 01期
关键词
ABSORPTION SPECTROSCOPY; TISSUE OPTICS; DIFFUSION THEORY;
D O I
10.1364/AO.34.000022
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
A diffusion model of noninvasive absorption spectroscopy was used to determine how the change in signal resulting from a point absorber depends on the position of that absorber relative to the source and detector. This is equivalent to calculating the relative probability that a photon will visit a certain location in tissue before its detection. Experimental mapping of the point-target response in tissue-simulating materials confirmed the accuracy of the model. For steady-state spectroscopy a simple relation was derived between the mean depth visited by detected photons, the source-detector separation, and the optical penetration depth. It was also demonstrated theoretically that combining a pulsed source with time-gated detection provides additional control over the spatial distribution of the photon-visit probability.
引用
收藏
页码:22 / 30
页数:9
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