POTENTIAL ANTIRADIATION AGENTS .I. PRIMARY AMINOALKANETHIOUSULFURIC ACIDS

被引：35

作者：

KLAYMAN, DL

GRENAN, MM

JACOBUS, DP

机构：

[1] Walter Reed Army Institute of Research, Division of Medicinal Chemistry, Washington

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a600

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of primary aminoalkanethiosulfuric acids, prepared by the reaction of the appropriate bromoalkylamine hydrobromide with sodium thiosulfate, was tested for potential radioprotective activity. In addition, the Bunte salts, (2-amino-2-thiazolm-5-yl)methylthiosulfuric acid and 2-amino-4-tluazolylmethylthiosulfuric acid, and 2-ammoethaneselenosulfuric acid were synthesized and screened similarly. The antiradiation activities of the corresponding aminothiols, where available, were determined and compared to the related thiosulfates. © 1969, American Chemical Society. All rights reserved.

引用

页码：510 / &

共 29 条

[1]

ABDOUSABET S, 1966, THESIS U MARYLAND

[2] *PROTECTION CONTRE LE RAYONNEMENT X PAR LA BETA-MERCAPTOETHYLAMINE [J].