SIMULTANEOUS INHIBITION OF ALTERNATIVE PATHWAYS OF CHOLESTEROL BIOSYNTHESIS BY 2 RELATED HYPOCHOLESTEREMIC AGENTS

被引：5

作者：

BLACK, ML

RODNEY, G

CAPPS, DB

机构：

[1] Research Laboratories, Parke, Davis and Co., Ann Arbor, MI

来源：

BIOCHEMICAL PHARMACOLOGY | 1968年 / 17卷 / 09期

关键词：

D O I：

10.1016/0006-2952(68)90096-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two related hypocholesteremic agents were administered, both singly and in combination, to rats and to monkeys. Analysis of the results in terms of chemical kinetic criteria provides, with more certainty than previously possible, a view of the mechanism by which the late stages of cholesterol biosynthesis are accomplished. Comparison of the structures and the different modes of action of the two agents illustrates the caution required in presuming that, when like structures exert like effects, they do so by the same mechanism. © 1968.

引用

页码：1803 / &

共 11 条

[1]

CLAYTON RB, 1963, J LIPID RES, V4, P166

[2] GAS-LIQUID CHROMATOGRAPHY OF STEROL METHYL ETHERS AND SOME CORRELATIONS BETWEEN MOLECULAR STRUCTURE AND RETENTION DATA [J].