GENETIC BASIS FOR UNRESPONSIVENESS TO LIPOPOLYSACCHARIDE IN C57BL-10CR MICE

The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to the Mup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F1 hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the same Lps locus, previously identified by the mutation detected in the C3H/HeJ strain. © 1978 Springer-Verlag New York Inc.