PREPARATION CONDITIONS AND EVALUATION OF THE STABILITY OF LIPID VESICLES (LIPOSOMES) USING THE MICROENCAPSULATION TECHNIQUE

被引：16

作者：

ISHII, F

TAKAMURA, A

OGATA, H

机构：

[1] Meiji Coll of Pharmacy, Tanashi, Jpn, Meiji Coll of Pharmacy, Tanashi, Jpn

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 1988年 / 9卷 / 01期

关键词：

DRUG PRODUCTS - Encapsulation - EMULSIONS - GLUCOSE;

D O I：

10.1080/01932698808943973

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The conditions for the preparation of lipid vesicles (liposomes) by the in-water drying method, one of the microencapsulation techniques, were described in detail. This process consists of the following steps: (I) dispersion of an aqueous solution of the drug to be encapsulated into an organic solvent to yield a water-in-oil emulsion, (II) dispersion of this w/o-type emulsion into an aqueous phase (distilled water), (III) formation of a lipid membrane on the surface of droplets by evaporation of the organic solvent from the oil phase, and (IV) removal of the free marker (drug) by ultracentrifugation or gel filtration through a Sephadex column.

引用

页码：1 / 15

页数：15

共 20 条

[1]

Bangham A D, 1968, Prog Biophys Mol Biol, V18, P29, DOI 10.1016/0079-6107(68)90019-9

[2] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].