CORTICOTROPIN-RELEASING FACTOR ENHANCES NORADRENALINE RELEASE IN THE RAT HYPOTHALAMUS ASSESSED BY INTRACEREBRAL MICRODIALYSIS

被引：45

作者：

EMOTO, H

YOKOO, H

YOSHIDA, M

TANAKA, M

机构：

[1] Department of Pharmacology, Kurume University School of Medicine, Kurume

来源：

BRAIN RESEARCH | 1993年 / 601卷 / 1-2期

关键词：

CORTICOTROPIN-RELEASING FACTOR; HYPOTHALAMUS; NORADRENALINE; INVIVO MICRODIALYSIS;

D O I：

10.1016/0006-8993(93)91722-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Corticotropin-releasing factor (CRF) at a dose of 3 mug administered intracerebroventricularly (i.c.v.) elicited increases in noradrenaline (NA) release, which was assessed by intracerebral microdialysis in the anterior hypothalamus of conscious rats. These increases persisted until 140 min after infusion of CRF. These results indicate (hat CRF enhances NA release in the hypothalamus, an effect which may underlie the 'stress-like' properties of CRF.

引用

页码：286 / 288

页数：3

共 18 条

[1] RELATIONSHIP OF ALPHA-1-ADRENERGIC-BINDING AND ALPHA-2-ADRENERGIC-BINDING SITES TO REGIONS OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS CONTAINING CORTICOTROPIN-RELEASING FACTOR AND VASOPRESSIN NEURONS [J].