ANTIBODY ENGINEERING

被引：15

作者：

NILSSON, B

机构：

[1] Pharmacia AB, Biopharmaceuticals, Department of Structural Biology, Mailcode: N62/6

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0959-440X(95)80028-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibody engineering has been an extremely intensive research area for many years. Recent achievements discussed in this review include: (i) significant improvements in the field of selection of antigen-specific antibody fragments on bacteriophages; (ii) new structural work, in particular using NMR; (iii) the cloning of essentially the complete set of human V-H genes; (iv) the use of antibodies to catalyze complicated chemical reactions; and (v) novel antibody fusion proteins to potentiate immune therapy. An interesting new development is the replacement of antibodies with more stable protein scaffolds for many future biotechnological applications.

引用

收藏

页码：450 / 456

页数：7

相关论文

共 77 条

[1] EFFICIENT SECRETION OF MURINE FAB FRAGMENTS BY ESCHERICHIA-COLI IS DETERMINED BY THE 1ST CONSTANT DOMAIN OF THE HEAVY-CHAIN [J].

ALFTHAN, K ;

TAKKINEN, K ;

SIZMANN, D ;

SEPPALA, I ;

IMMONEN, T ;

VANNE, L ;

KERANEN, S ;

KAARTINEN, M ;

KNOWLES, JKC ;

TEERI, TT .

GENE, 1993, 128 (02) :203-209

[2] IN-VITRO EVOLUTION OF A NEUTRALIZING HUMAN-ANTIBODY TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO ENHANCE AFFINITY AND BROADEN STRAIN CROSS-REACTIVITY [J].

BARBAS, CF ;

HU, D ;

DUNLOP, N ;

SAWYER, L ;

CABABA, D ;

HENDRY, RM ;

NARA, PL ;

BURTON, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3809-3813

[3] ASSEMBLY OF COMBINATORIAL ANTIBODY LIBRARIES ON PHAGE SURFACES - THE GENE-III SITE [J].

BARBAS, CF ;

KANG, AS ;

LERNER, RA ;

BENKOVIC, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) :7978-7982

[4] RAPID HUMANIZATION OF THE FV OF MONOCLONAL-ANTIBODY B3 BY USING FRAMEWORK EXCHANGE OF THE RECOMBINANT IMMUNOTOXIN B3(FV)-PE38 [J].

BENHAR, I ;

PADLAN, EA ;

JUNG, SH ;

LEE, B ;

PASTAN, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :12051-12055

[5] CRYSTAL-STRUCTURE OF THE BETA-CHAIN OF A T-CELL ANTIGEN RECEPTOR [J].

BENTLEY, GA ;

BOULOT, G ;

KARJALAINEN, K ;

MARIUZZA, RA .

SCIENCE, 1995, 267 (5206) :1984-1987

[6] SINGLE-CHAIN ANTIGEN-BINDING PROTEINS [J].

BIRD, RE ;

HARDMAN, KD ;

JACOBSON, JW ;

JOHNSON, S ;

KAUFMAN, BM ;

LEE, SM ;

LEE, T ;

POPE, SH ;

RIORDAN, GS ;

WHITLOW, M .

SCIENCE, 1988, 242 (4877) :423-426

[7] THE IMMUNOGLOBULIN FOLD - STRUCTURAL CLASSIFICATION, SEQUENCE PATTERNS AND COMMON CORE [J].

BORK, P ;

HOLM, L ;

SANDER, C .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 242 (04) :309-320

[8] ANTIBODY-CATALYZED PRODRUG ACTIVATION [J].

CAMPBELL, DA ;

GONG, B ;

KOCHERSPERGER, LM ;

YONKOVICH, S ;

GALLOP, MA ;

SCHULTZ, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :2165-2166

[9] HUMANIZATION OF AN ANTI-P185HER2 ANTIBODY FOR HUMAN CANCER-THERAPY [J].

CARTER, P ;

PRESTA, L ;

GORMAN, CM ;

RIDGWAY, JBB ;

HENNER, D ;

WONG, WLT ;

ROWLAND, AM ;

KOTTS, C ;

CARVER, ME ;

SHEPARD, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4285-4289

[10] MUTATIONAL ANALYSIS OF THE INTERACTION BETWEEN STAPHYLOCOCCAL PROTEIN-A AND HUMAN IGG(1) [J].

CEDERGREN, L ;

ANDERSSON, R ;

JANSSON, B ;

UHLEN, M ;

NILSSON, B .

PROTEIN ENGINEERING, 1993, 6 (04) :441-448

← 1 2 3 4 5 6 7 8 →