ADRENOCORTICOTROPIN-INDUCED HYPERTENSION IN RATS - ROLE OF PROGESTERONE AND DIGOXIN-LIKE SUBSTANCES

被引：22

作者：

LI, M ^{[1
]}

WONG, KS ^{[1
]}

MARTIN, A ^{[1
]}

WHITWORTH, JA ^{[1
]}

机构：

[1] ST GEORGE HOSP,DEPT MED,KOGARAH,NSW 2217,AUSTRALIA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 01期

关键词：

ADRENOCORTICOTROPIN; DIGOXIN-LIKE SUBSTANCES; HYPERTENSION; PROGESTERONE;

D O I：

10.1093/ajh/7.1.59

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Adrenocorticotrophin (ACTH) administration raises blood pressure in humans, sheep, and the rat. ACTH hypertension can be reproduced in sheep by combined infusion of aldosterone, 17 alpha-OH-progesterone, and 17 alpha,20 alpha-OH-progesterone, and in humans by cortisol. In the rat, ACTH hypertension is probably due to corticosterone. Progesterone treatment can prevent ACTH-induced hypertension in sheep. This study examined the ability of progesterone to antagonize the onset and development of ACTH-induced hypertension in Sprague-Dawley rats (n = 44). We also investigated the relationship of plasma digoxin-like substances (DLS) to ACTH hypertension. ACTH (0.5 mg/kg/day) significantly increased blood pressure (+24 +/- 5 mm Hg, P < .001) in association with an increase of water intake, urine output, and plasma sodium concentration, and a decrease of body weight and plasma potassium concentration. ACTH increased plasma DLS (+132 +/- 18 pg/mL, P < .01), and there was a positive correlation between DLS and blood pressure (r = 0.68, n = 22, P < .001). Progesterone (50 mg/kg/day) did not block the development of ACTH-induced hypertension in the rat. Although progesterone prevented the ACTH-induced rise in plasma sodium and glucose concentration, it did not prevent the decrease in plasma potassium concentration. The failure of progesterone to prevent ACTH-induced hypertension in the rat argues against a common ''hypertensinogenic'' mechanism for ACTH hypertension in sheep and rat. DLS may play a role in ACTH-induced hypertension in the rat.

引用

页码：59 / 68

页数：10

共 48 条

[1]

Scoggins B.A., Denton D.A., Whitworth J.A., Et al., ACTH dependent hypertension, Clin Exp Hypertens [A], 6, pp. 599-646, (1984)

[2]

Whitworth J.A., Hewitson T.D., Li M., Wilson R.S., Et al., Adrenocorticotrophin-induced hypertension in the rat: Haemodynamic, metabolic and morphological characteristics, J Hypertens, 8, pp. 27-36, (1990)

[3]

Whitworth J.A., Saines D., Scoggins B.A., Blood pressure and metabolic effects of ACTH in normotensive man, Clin Exp Hypertens, 5, pp. 501-522, (1983)

[4]

Spence C.D., Coghlan J.P., Denton D.A., Et al., Adrenocortical steroid requirements for initiation of ACTH-dependent hypertension in sheep, Clin Exp Pharmacol Physiol, 16, pp. 759-772, (1989)

[5]

Whitworth J.A., Scoggins B.A., A "hypertensinogenic" class of steroid hormone activity in man?, Clin Exp Pharmacol Physiol, 3, pp. 163-166, (1990)

[6]

Haack D., Mohring B., Petri M., Et al., Comparative study on development of corticosterone and DOCA hypertension in rats, Am J Physiol, 233, pp. F403-F411, (1977)

[7]

Haack D., Engel R., Vecsei P., The effect of chronic ACTH treatment on blood pressure and urinary excretion of steroids in the rat, Klin Wochenschr, 56, pp. 183-186, (1978)

[8]

Armstrong J.G., Hypotensive action of progesterone in experimental and human hypertension, Proc Soc Exp Biol Med, 102, pp. 452-455, (1959)

[9]

Wambach G., Higgins J.R., Antihypertensive effect of progesterone in rats with mineralocorticoid-induced hypertension, Am J Physiol, 236, pp. E366-E370, (1979)

[10]

Susie D., Radujkovic G., Kentera D., The mechanism of the antihypertensive action of progesterone: Haemodynamic studies in rats with partial nephrectomy salt hypertension, Clin Exp Hypertens, A5, pp. 353-366, (1983)

← 1 2 3 4 5 →