NORTRIPTYLINE-INDUCED FULMINANT HEPATIC-FAILURE

被引：9

作者：

BERKELHAMMER, C

KHER, N

BERRY, C

LARGOSA, A

机构：

[1] EHS CHRIST HOSP & MED CTR,DEPT FAMILY PRACTICE,OAK LAWN,IL 60453

[2] EHS CHRIST HOSP & MED CTR,DEPT PATHOL,OAK LAWN,IL 60453

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1995年 / 20卷 / 01期

关键词：

NORTRIPTYLINE; FULMINANT HEPATIC FAILURE; DRUG-INDUCED HEPATITIS; TRICYCLIC ANTIDEPRESSANTS;

D O I：

10.1097/00004836-199501000-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe, to our knowledge, the first reported case of nortriptyline-induced fulminant hepatic failure. This tricyclic antidepressant drug was taken by a postmenopausal woman for 64 days before her presentation. The absence of fever, rash, or marked eosinophilia, the predominant zone 3 necrosis with bridging, and the latent period favor a metabolic idiosyncratic reaction. The fatal outcome underscores the importance of recognizing the association and discontinuing the offending agent.

引用

页码：54 / 56

页数：3

共 23 条

[1] TOXICITY OF TRICYCLIC ANTIDEPRESSANTS TO ISOLATED RAT HEPATOCYTES [J].