DEFECTIVE CANDIDACIDAL CAPACITY OF POLYMORPHONUCLEAR LEUKOCYTES IN CHRONIC GRANULOMATOUS DISEASE OF CHILDHOOD

被引：70

作者：

OH, MHK

RODEY, GE

GOOD, RA

CHILGREN, RA

QUIE, PG

机构：

[1] Department of Pediatrics, University of Minnesota College of Medical Sciences, Minneapolis, MN

[2] Department of Laboratory Medicine, University of Minnesota College of Medical Sciences, Minneapolis, MN

来源：

JOURNAL OF PEDIATRICS | 1969年 / 75卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(69)80403-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease of childhood phagocytize C. albicans normally but are unable to kill the intracellular organisms. PMN from normal human adults and newborn infants phagocytize and kill approximately 30 per cent of intracellular organisms in 60 minutes. Sera from control subjects and patients with chronic granulomatous disease are actively opsonic for C. albicans. Heated serum is not opsonic but opsonic capacity can be restored by addition of C. albicans absorbed fresh serum. Both specific heat-stable and nonspecific heat-labile serum factors are necessary for opsonization of C. albicans. © 1969 The C. V. Mosby Company.

引用

页码：300 / +

页数：1

共 9 条

[1] A FATAL GRANULOMATOUS DISEASE OF CHILDHOOD - THE CLINICAL, PATHOLOGICAL, AND LABORATORY FEATURES OF A NEW SYNDROME [J].