POTENTIAL ANTI-MICROBIALS .1. SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF SOME NEW THIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

被引：31

作者：

BADAWEY, ESAM ^{[1
]}

RIDA, SM ^{[1
]}

HAZZA, AA ^{[1
]}

FAHMY, HTY ^{[1
]}

GOHAR, YM ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,FAC SCI,DIV MICROBIOL,ALEXANDRIA,EGYPT

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 02期

关键词：

THIAZOLO[4,5-D]PYRIMIDINES; ANTIBACTERIAL; ANTIFUNGAL;

D O I：

10.1016/0223-5234(93)90001-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of several 2,3-dihydro-3,6-diaryl-5-mercapto-2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones and related compounds are discussed. Some members of the series displayed broad in vitro anti-bacterial and anti-fungal activities. Three compounds were screened for anti-HIV potency but were inactive.

引用

页码：91 / 96

页数：6

共 12 条

[1] BENZIMIDAZOLE CONDENSED RING-SYSTEMS .6. ORGANIC AZIDES IN HETEROCYCLIC SYNTHESIS .10. SYNTHESIS OF SOME SUBSTITUTED PYRIMIDO[1,6-A]-BENZIMIDAZOLES AS POTENTIAL ANTIMICROBIAL AGENTS [J].

BADAWEY, ESAM ;

RIDA, SM ;

SOLIMAN, FSG ;

KAPPE, T .

MONATSHEFTE FUR CHEMIE, 1989, 120 (12) :1159-1164

[2] THIAZOLO[5,4-D]PYRIMIDINE DERIVATIVES AS AMPLIFIERS OF PHLEOMYCIN AGAINST ESCHERICHIA-COLI [J].

BROWN, DJ ;

DUNLAP, WC ;

GRIGG, GW ;

KELLY, J .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (08) :1775-1783

[3]

DEVANI MB, 1977, ARZNEIMITTELFORSCH, V27, P1652

[4]

FOYE WO, 1989, PRINCIPLES MED CHEM, P652

[5] HETEROCYCLEN AUS CH-ACIDEN NITRILEN .6. REAKTION VON METHYLENAKTIVEN NITRILEN MIT SENFOLEN UND SCHWEFEL [J].

GEWALD, K .

JOURNAL FUR PRAKTISCHE CHEMIE, 1966, 32 (1-2) :26-&

[6] SYNTHESIS OF 4-SUBSTITUTED 5-AMINO-2-(BETA-D-RIBOFURANOSYL)THIAZOLES AND 4-SUBSTITUTED 5-AMINO-2-(BETA-D-RIBOFURANOSYL)SELENAZOLES AND THEIR RESPECTIVE CONVERSION INTO 2-(BETA-D-RIBOFURANOSYL)THIAZOLO[5,4-D]PYRIMIDINES AND 2-(BETA-D-RIBOFURANOSYL)SELENAZOLO[5,4-D]PYRIMIDINES - A NEW SYNTHESIS OF TIAZOFURIN AND SELENAZOFURINN [J].

HENNEN, WJ ;

HINSHAW, BC ;

RILEY, TA ;

WOOD, SG ;

ROBINS, RK .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (10) :1741-1746

[7] INHIBITION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYL TRANSFERASE [J].

JADHAV, AL ;

TOWNSEND, LB ;

NELSON, JA .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (07) :1057-1062

[8] ANTIBACTERIAL ACTIVITY OF SOME ESSENTIAL OILS AND THEIR COMBINATIONS [J].

JAIN, SR ;

KAR, A .

PLANTA MEDICA, 1971, 20 (02) :118-&

[9]

Jones R., 1985, MANUAL CLIN MICROBIO, P972

[10]

ROBINS RK, 1836, Patent No. 20136

← 1 2 →