MENIERES-DISEASE AND ANTIBODY REACTIVITY TO HERPES-SIMPLEX VIRUS TYPE-1 POLYPEPTIDES

被引：25

作者：

BERGSTROM, T

EDSTROM, S

TJELLSTROM, A

VAHLNE, A

机构：

[1] Departments of Clinical Virology and Otolaryngology, University of Göteborg, Sahlgrens Hospital, Göteborg

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1992年 / 13卷 / 05期

关键词：

D O I：

10.1016/0196-0709(92)90051-T

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purpose: It has been reported that the inner ear is capable of responding to antigen challenge. In this study, we have investigated the antibody reactivity to herpes simplex virus 1 (HSV-1) proteins in sera from patients with Ménière's disease. Patients and Materials: Serum from 21 patients scheduled to undergo endolymphatic sac decompression for Ménière's disease was obtained. The sera from 21 age- and sex-matched individuals without a history of ear disease served as the control. An enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies to HSV-1, HSV-2 cytomegalovirus (CMV), varicella-zoster virus (VZV), and measles virus. Immunoblotting was used to confirm and further evaluate the HSV-1 antibody response. Results: All but one patient had antibodies to HSV-1. ELISA mean log titers were significantly lower in the patient group to CMV and VZV when compared with controls. A pattern of generally higher antibody reactivity in patients with Ménière's disease was demonstrated to the individual SDS-PAGE HSV-1 polypeptides as judged by immunoblotting. Conclusion: The HSV-1 antibody response found in patients with Ménière's disease may indicate viral reactivation and denotes the importance of further studies on the role of infectious agents in this disease. © 1992.

引用

页码：295 / 300

页数：6

共 31 条

[1]

Arenberg, Rask-Andersen, Wilbrand, Et al., The surgical anatomy of the endolyphatic sac, Arch Otolaryngol Head Neck Surg, 103, pp. 1-11, (1977)

[2]

Paparella, deSouca, Mancini, Ménière's syndrome and otitis media, Laryngoscope, pp. 1408-1415, (1983)

[3]

Roitman, Talmi, Finkelstein, Et al., Acoustic trauma-induced Ménière's syndrome, ORL J Otohinolaryngol Relat Spac, 51, pp. 246-250, (1989)

[4]

Harris, Immunology of the inner ear: Response of the inner ear to antigen challenge, Otolaryngol Head Neck Surg, 91, pp. 18-23, (1983)

[5]

Hughes, Kinney, Barna, Et al., Auto-immunity in otology, Am J Otol, 7, pp. 197-199, (1986)

[6]

Brookes, Circulating immune complexes in Ménière's disease, Arch Otolaryngol Head Neck Surg, 112, pp. 536-540, (1986)

[7]

Wilson, The relationship of the herpesvirus family to sudden hearing loss: A prospective clinical study and literature review, Laryngoscope, 96, pp. 870-877, (1986)

[8]

Hanner, Edstrom, Rosenhall, Et al., Hearing impairment in patients with antibody production against Borrelia Burgdorferi antigen, Lancet, 1, pp. 13-15, (1989)

[9]

Jeansson, Forsgren, Svennerholm, Evaluation of solubilized herpes simplex virus membrane antigen by enzyme-linked immunosorbent assay, J Clin Microbiol, 18, pp. 1160-1166, (1983)

[10]

Svennerholm, Olofsson, Jeansson, Et al., Herpes simples virus type-selective enzyme-linked immunosorbent assay with helix pomatia lectin-purified antigens, J Clin Microbiol, 19, pp. 235-239, (1984)

← 1 2 3 4 →