CLONING AND CHARACTERIZATION OF THE TANDEMLY ARRANGED BOVINE LYMPHOTOXIN AND TUMOR-NECROSIS-FACTOR-ALPHA GENES

被引：34

作者：

CLUDTS, I ^{[1
]}

CLEUTER, Y ^{[1
]}

KETTMANN, R ^{[1
]}

BURNY, A ^{[1
]}

DROOGMANS, L ^{[1
]}

机构：

[1] FAC AGRON GEMBLOUX, GEMBLOUX, BELGIUM

来源：

CYTOKINE | 1993年 / 5卷 / 04期

关键词：

CYTOKINE; BOVINE GENOME; LYMPHOTOXIN; TUMOR NECROSIS FACTOR;

D O I：

10.1016/1043-4666(93)90065-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The screening of a bovine genomic library with a human tumour necrosis factor-αTNF-α) cDNA probe resulted in the isolation of a 7.2 kb DNA fragment containing the entire bovine TNF-α gene. Analysis of this genomic clone showed that it also contains the bovine lymphotoxin (LT, TNF-β) gene. Comparison to published sequences of human, murine, ovine nd rabbit counterparts allowed us to delineate the coding sequences, the promoters and the enhancers of these two genes. Sequences involved in the regulation of translation and in the mRNa stability were found in the 3′ untranslated regions. © 1993 Academie Press Limited.

引用

页码：336 / 341

页数：6

共 35 条

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