COGNITIVE FUNCTIONS OF CORTICAL ACH - LESSONS FROM STUDIES ON TRANSSYNAPTIC MODULATION OF ACTIVATED EFFLUX

被引：93

作者：

SARTER, MF ^{[1
]}

BRUNO, JP ^{[1
]}

机构：

[1] OHIO STATE UNIV,NEUROSCI PROGRAM,COLUMBUS,OH 43210

来源：

TRENDS IN NEUROSCIENCES | 1994年 / 17卷 / 06期

关键词：

D O I：

10.1016/0166-2236(94)90001-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively activated cortical ACh efflux. The determination of behavioral functions which are mediated via activated cortical ACh efflux, and therefore subject to the effects of basal forebrain GABA-cholinergic manipulations, should promote analyses of the functions of cortical ACh. Trans-synaptic approaches to enhance activated cortical ACh efflux offer some potential for the treatment of cognitive dysfunctions associated with impaired cortical cholinergic transmission.

引用

页码：217 / 221

页数：5

共 83 条

[1] CHOLINERGIC MODULATION OF FREQUENCY RECEPTIVE-FIELDS IN AUDITORY-CORTEX .2. FREQUENCY-SPECIFIC EFFECTS OF ANTICHOLINESTERASES PROVIDE EVIDENCE FOR A MODULATORY ACTION OF ENDOGENOUS ACH [J].