HORMONE REPLACEMENT THERAPY AND SERUM ANGIOTENSIN CONVERTING-ENZYME ACTIVITY IN POSTMENOPAUSAL WOMEN

被引：174

作者：

PROUDLER, AJ ^{[1
]}

AHMED, AIH ^{[1
]}

CROOK, D ^{[1
]}

FOGELMAN, I ^{[1
]}

RYMER, JM ^{[1
]}

STEVENSON, JC ^{[1
]}

机构：

[1] GUYS HOSP,DEPT NUCL MED,LONDON SE1 9RT,ENGLAND

来源：

LANCET | 1995年 / 346卷 / 8967期

关键词：

D O I：

10.1016/S0140-6736(95)92114-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms by which hormone replacement therapy (HRT) reduces the risk of coronary heart disease (CHD) are incompletely understood, but may include direct arterial effects. We examined the effect of oestrogen/progestagen HRT on serum angiotensin-converting-enzyme (ACE) activity in postmenopausal women. After 6 months, ACE activity was reduced by 20% (p<0.001) on average in 28 treated women but remained unchanged in 16 controls. Serum ACE activity is modifiable by gonadal steroids and changes in serum ACE may represent a novel mechanism by which HRT reduces CHD risk in women.

引用

页码：89 / 90

页数：2

共 9 条

[1]

ALHENCGELAS F, 1991, J LAB CLIN MED, V117, P33

[2]

BUTTERY JE, 1993, CLIN CHEM, V39, P312

[3] PLASMA-LEVEL AND GENE POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME IN RELATION TO MYOCARDIAL-INFARCTION [J].