INDUCTION OF NONRESPONSIVENESS IN HUMAN ALLERGEN-SPECIFIC TYPE-2 T-HELPER CELLS

被引：49

作者：

YSSEL, H ^{[1
]}

FASLER, S ^{[1
]}

LAMB, J ^{[1
]}

DEVRIES, JE ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOL, LONDON SW7 2BB, ENGLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0952-7915(94)90003-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of allergen-reactive human T helper (Th)2 cells in the absence of professional antigen-presenting cells, induces non-responsiveness or anergy in these cells in vitro. This induction of anergy is accompanied by phenotypic modulation and altered cytokine production. furthermore, peptide-treated Th2 cells fail to provide B-cell help for IgE synthesis. Recent studies indicate that impaired signal transduction via the T-cell receptor may account for the lack of responsiveness to antigenic stimulation. Here, we review present knowledge on the cell biology of non-responsive or anergic Th2 cells.

引用

页码：847 / 852

页数：6

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