THE INTRA-ADRENAL DISTRIBUTION OF INTRINSIC AND EXTRINSIC NITRERGIC NERVE-FIBERS IN THE RAT

被引:14
作者
AFEWORK, M
RALEVIC, V
BURNSTOCK, G
机构
[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,LONDON WC1E 6BT,ENGLAND
[2] UNIV LONDON UNIV COLL,CTR NEUROSCI,LONDON WC1E 6BT,ENGLAND
关键词
ADRENAL GLAND; NITRIC OXIDE SYNTHASE; INNERVATION; DENERVATION;
D O I
10.1016/0304-3940(95)11514-W
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The intra-adrenal distribution of nitric oxide synthase (NOS)-immunoreactive nerve fibres was studied in rats subjected to various denervations. Splanchnic nerve section eliminated the NOS-immunoreactive nerve fibres which innervate adrenal chromaffin and neuronal cells. It did not affect those innervating blood vessels and zona glomerulosa, which instead were affected by adrenal demedullation. Guanethidine, 6-hydroxydopamine (6-OHDA) and capsaicin treatments, however, did not produce any change. These results suggest that nitrergic nerves which innervate adrenal medullary cells are extrinsic (largely preganglionic sympathetic), whilst those innervating the zona glomerulosa and the majority of adrenal vessels are intrinsic, and that they do not belong to nerves sensitive to the sympathetic nerve neurotoxins, guanethidine and 6-OHDA, or the sensory neurotoxin, capsaicin.
引用
收藏
页码:109 / 112
页数:4
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