PRECORE AND X-REGION MUTANTS IN HEPATITIS-B VIRUS-INFECTIONS AMONG RENAL DIALYSIS PATIENTS

被引:18
作者
FEITELSON, MA
DUAN, LX
GUO, J
HORIIKE, N
MCINTYRE, G
BLUMBERG, BS
THOMAS, HC
CARMAN, W
机构
[1] FOX CHASE CANC CTR,PHILADELPHIA,PA 19111
[2] EHIME UNIV,SCH MED,DEPT INTERNAL MED 3,MATSUYAMA,EHIME 790,JAPAN
[3] UNIV GLASGOW,INST VIROL,GLASGOW G11 5JR,LANARK,SCOTLAND
[4] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT MED,LONDON W2 1PG,ENGLAND
关键词
HEPATITIS B VIRUS; NON-A; NON-B HEPATITIS; PATHOGENESIS; PRECORE MUTANTS; VIRUS VARIATION; X DELETION MUTANTS;
D O I
10.1111/j.1365-2893.1995.tb00068.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatitis B virus (HBV) variants containing mutations within the X and the precore regions of the viral genome were demonstrated by polymerase chain reaction (PCR) amplification and DNA sequencing in renal dialysis patients with different serological patterns of HBV infection. Among carriers, X region deletion mutants predominated in patients who lost hepatitis B e antigen (HBeAg), or developed anti-HBe, but not in persistently HBeAg-positive patients. The precore region remained wild type in all carriers whether or not they seroconverted from HBeAg to anti-HBe. The frequency of precore and X region mutants was greatest among cion-carrier patients with viral antibodies as the only indication of infection and among patients with non-A, non-B hepatitis (NANBH), suggesting an inverse relationship between the presence of wild type HBV markers and the presence of HBV mutants. Furthermore, the detection of one but not the other mutation in many serum samples suggests that these mutations are independently selected for during infection. Finally, the absence of HBV DNA in 21 'uninfected' dialysis patients with normal transaminases and no viral serology, suggests that replication of these mutants is associated with hepatitis. These results have important implications for HBV screening and treatment, as well as for the pathogenesis of chronic infection.
引用
收藏
页码:19 / 31
页数:13
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