STRAIN AND SEX VARIATIONS IN SENSITIVITY OF MICE TO DOMINANT-LETHAL INDUCTION WITH ETHYL METHANESULFONATE

被引：64

作者：

GENEROSO, WM

RUSSELL, WL

机构：

[1] Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN

来源：

MUTATION RESEARCH | 1969年 / 8卷 / 03期

关键词：

2-methoxy-6-chloro-9-[3-(ethyl-2-chloroethyl)aminopropylamino]-acridine·2HCl; EMS; ethyl methanesulfonate; ICR-170; methyl methanesulfonate; MMS; MNNG; N-methyl-N′-nitro-N-nitrosoguanidine;

D O I：

10.1016/0027-5107(69)90077-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Male and female mice from two hybrid strains and a random-bred one were subjected to dominant-lethal induction with ethyl methanesulfonate. In female mice, 1 strain revealed a strong mutagenic action of ethyl methanesulfonate while the other 2 strains did not. In male mice, all 3 strains exhibited high sensitivity to the mutagenic action of ethyl methanesulfonate with only minor strain differences. The results thus revealed the existence of large sex differences in 2 of the 3 strains and large strain differences in the response of females. © 1969.

引用

页码：589 / &

共 13 条

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