CHROMOSOME BREAKING ACTIVITY OF HUMAN FECES AND ITS ENHANCEMENT BY TRANSITION-METALS

被引：12

作者：

STICH, HF

KUHNLEIN, U

机构：

[1] Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 24卷 / 03期

关键词：

D O I：

10.1002/ijc.2910240303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chloroform‐methanol extracts from human fecal samples were found to contain compounds which induce chromosome aberrations in Chinese hamster ovary cells. The induction of chromosome aberrations is stimulated by Cu2+ or Mn2+ and inhibited by Fe2+ or Fe3+. Addition of catalase to the fecal extract or the mixture of fecal extract and Mn2+ reduced the frequency of chromosome aberrations. These properties are indicative of hydroxyradical producing agents. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：284 / 287

页数：4

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