MUSCARINIC CHOLINERGIC AND PREGANGLIONIC PHYSIOLOGICAL STIMULATION INCREASE CYCLIC-GMP LEVELS IN GUINEA-PIG SUPERIOR CERVICAL-GANGLIA

被引：21

作者：

WAMSLEY, JK

WEST, JR

BLACK, AC

WILLIAMS, TH

机构：

[1] Department of Anatomy, College of Medicine, University of Iowa, Iowa City, Iowa

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 03期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb04590.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Incubation of guinea‐pig superior cervical ganglia in 500μ4mUm‐carbachol for 2min increased cyclic GMP levels 530% over control values. The increase was blocked by prior incubation in 300μmatropine. No increase in cyclic GMP levels after incubation in 100 μm‐l‐norepinephrine was observed. Preganglionic physiological stimulation for 8 min at 10 Hz increased cyclic GMP levels 180% over control values. We conclude that both muscarinic cholinergic and preganglionic physiological stimulation increase cyclic GMP levels in guinea pig superior cervical ganglia, while norepinephrine has no effect. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1033 / 1035

页数：3

共 17 条

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