THE AMYLOID BETA-PROTEIN PRECURSOR IS LOCALIZED IN SMOOTH-MUSCLE CELLS OF LEPTOMENINGEAL VESSELS

被引：54

作者：

SHOJI, M

HIRAI, S

HARIGAYA, Y

KAWARABAYASHI, T

YAMAGUCHI, H

机构：

[1] Department of Neurology, Gunma University School of Medicine, Gunma

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 01期

关键词：

Amyloid β-protein precursor; Cerebral amyloid angiopathy; Immunocytochemistry; Smooth muscle cell;

D O I：

10.1016/0006-8993(90)90665-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined leptomeningeal vessels using 2 different antisera which recognized both terminal ends of amyloid β-protein precursor (APP). Both antisera recognized a 120-kDa protein from leptomeningeal vessels. Immunocytochemistry showed that APP was localized in the smooth muscle cells of leptomeningeal vessels. These results indicated that the smooth muscle cells of leptomeningeal vessels contained full-length native APP, and that the cerebrovascular amyloid in the leptomeningeal vessels was derived from this APP. © 1990.

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页码：113 / 116

页数：4

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