EFFECT OF WORK-INDUCED HYPERTROPHY ON SKELETAL-MUSCLE OF TUMOR-BEARING AND NON-TUMOR-BEARING RATS

被引:21
作者
NORTON, JA
LOWRY, SF
BRENNAN, MF
机构
关键词
D O I
10.1152/jappl.1979.46.4.654
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Synergistic muscles (soleus and plantaris) from a gastrocnemius-tenotomized hindlimb were compared to the same muscles in a sham-operated hindlimb in both tumor-bearing and non-tumor-bearing rats. In nontumor-bearing animals muscle from the tenotomized hindlimb had a significant increase in wet weight (26%), percent water (5%), and total nitrogen/muscle (10%) consistent with muscular hypertrophy. In tumor-bearing animals, muscle from the tenotomized hindlimb had a significant increase in wet weight and percent water, but there was no significant difference in total nitrogen/muscle. As the tumor burden increased, the final muscle weight, in both the tenotomized and sham-operated hindlimb, was found to decrease proportionately. Only in animals with large (23% body wt) tumor burdens did hypertrophied muscle weigh significantly less than sham-operated muscle from nontumor-bearing animals. This indicated that, in rats with large tumor burdens, work-induced hypertrophy was unable to preserve muscle mass despite the fact that hypertrophied muscle was 24% heavier than contralateral sham-operated muscle.
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页码:654 / 657
页数:4
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