EPSTEIN-BARR VIRUS IN NASAL T-CELL LYMPHOMAS IN PATIENTS WITH LETHAL MIDLINE GRANULOMA

被引：481

作者：

HARABUCHI, Y

YAMANAKA, N

KATAURA, A

IMAI, S

KINOSHITA, T

MIZUNO, F

OSATO, T

机构：

[1] HOKKAIDO UNIV,SCH MED,INST CANC,DEPT VIROL,SAPPORO,HOKKAIDO 060,JAPAN

[2] SAPPORO MED COLL,DEPT OTOLARYNGOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

LANCET | 1990年 / 335卷 / 8682期

关键词：

D O I：

10.1016/0140-6736(90)90002-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Five cases of lethal midline granuloma were identified histologically and phenotypically as peripheral T-cell lymphomas. Epstein-Barr virus (EBV) DNA was detected in the nasal tumour biopsy specimens by Southern blotting and in-vitro hybridisation with simultaneous detection of EBV-determined nuclear antigen (EBNA) and T-cell surface markers by two-colour immunofluorescence. Further immunofluorescence and northern blotting revealed that EBNA2 gene and also latent membrane protein gene were expressed in the nasal tumour cells. The patients had high titres of antibodies to EBV. These findings suggest that lethal midline granuloma is causally associated with EBV. © 1990.

引用

页码：128 / 130

页数：3

共 19 条

[1] ABO W, 1982, LANCET, V1, P1272
[2] EPSTEIN MA, 1979, EPSTEINBARR VIRUS, P1
[3] IDENTIFICATION OF LYMPHOCYTE SUBSETS AND NATURAL-KILLER CELLS IN HEAD AND NECK CANCERS - AN IMMUNOHISTOLOGICAL STUDY USING MONOCLONAL-ANTIBODIES
HARABUCHI, Y
YAMANAKA, N
KATAURA, A
[J]. ARCHIVES OF OTO-RHINO-LARYNGOLOGY-ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE, 1985, 242 (01): : 89 - 97
[4] EPSTEIN-BARR VIRUS-SPECIFIC IGA SERUM ANTIBODIES AS AN OUTSTANDING FEATURE OF NASOPHARYNGEAL CARCINOMA
HENLE, G
HENLE, W
[J]. INTERNATIONAL JOURNAL OF CANCER, 1976, 17 (01) : 1 - 7
[5] DIFFERENTIAL REACTIVITY OF HUMAN SERUMS WITH EARLY ANTIGENS INDUCED BY EPSTEIN-BARR VIRUS
HENLE, W
HENLE, G
ZAJAC, BA
PEARSON, G
WAUBKE, R
SCRIBA, M
[J]. SCIENCE, 1970, 169 (3941) : 188 - &
[6] T-CELL LYMPHOMAS CONTAINING EPSTEIN-BARR VIRAL-DNA IN PATIENTS WITH CHRONIC EPSTEIN-BARR VIRUS-INFECTIONS
JONES, JF
SHURIN, S
ABRAMOWSKY, C
TUBBS, RR
SCIOTTO, CG
WAHL, R
SANDS, J
GOTTMAN, D
KATZ, BZ
SKLAR, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (12) : 733 - 741
[7] EPSTEIN-BARR VIRUS GENOME-POSITIVE LYMPHOCYTES-T IN A BOY WITH CHRONIC ACTIVE EBV INFECTION ASSOCIATED WITH KAWASAKI-LIKE DISEASE
KIKUTA, H
TAGUCHI, Y
TOMIZAWA, K
KOJIMA, K
KAWAMURA, N
ISHIZAKA, A
SAKIYAMA, Y
MATSUMOTO, S
IMAI, S
KINOSHITA, T
KOIZUMI, S
OSATO, T
KOBAYASHI, I
HAMADA, I
HIRAI, K
[J]. NATURE, 1988, 333 (6172) : 455 - 457
[8] LIPPMAN SM, 1987, CANCER, V59, P936, DOI 10.1002/1097-0142(19870301)59:5<936::AID-CNCR2820590514>3.0.CO
[9] 2-F
[10] OKANO M, 1984, LANCET, V2, P933

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