INVESTIGATIONS ON MUTAGENICITY AND GENOTOXICITY OF PENTAMIDINE AND SOME RELATED TRYPANOCIDAL DIAMIDINES

被引：21

作者：

STAUFFERT, I ^{[1
]}

PAULINI, H ^{[1
]}

STEINMANN, U ^{[1
]}

SIPPEL, H ^{[1
]}

ESTLER, CJ ^{[1
]}

机构：

[1] INST BOT & PHARMAZEUT BIOL,ERLANGEN,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 02期

关键词：

Ames test; Pentamidine; Sister-chromatid exchange (SCE); Trypanocidal diamidines;

D O I：

10.1016/0165-7992(90)90006-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pentamidine, DAPI and some related compounds (DAI, 6-Br-AI, DPTN, DIPI, 3-Am-DAI, DiaPBF) were investigated in 2 different screening test systems for their potential mutagenic and cytotoxic effects, in the light of their binding to DNA. In the Ames test using Salmonella typhimurium strains TA98 and TA100 with and without metabolic activation no mutagenic effects could be observed. All diamidines tested, except DAI, were toxic at concentrations of 0.5 and 1.0 μmole/plate. In the sister-chromatid exchange (SCE) assay with human peripheral lymphocytes all compounds tested were growth-retarding particularly in the Go phase. A significant induction of SCEs could only be seen after treatment with the monoamidino compound 6-Br-AI at a concentration of 100 μmole/I. It is concluded from the data obtained that pentamidine and related diamodines in the 2 assays tested show no mutagenic or genotoxic effects, in spite of their tight binding to DNA. © 1990.

引用

页码：93 / 98

页数：6

共 21 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].