HARMAN IN HUMAN-PLATELETS

被引：62

作者：

BIDDER, TG

SHOEMAKER, DW

BOETTGER, HG

EVANS, M

CUMMINS, JT

机构：

[1] CALTECH,JET PROP LAB,PASADENA,CA 91103

[2] VET ADM HOSP,MED CTR,SEPULVEDA,CA 91343

来源：

LIFE SCIENCES | 1979年 / 25卷 / 02期

基金：

美国国家航空航天局; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0024-3205(79)90387-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The β-carbolines present in human platelets have been extracted with diethyl ether, isolated by liquid column chromatography and thin-layer chromatography (TLC), and identified by ultraviolet fluorimetry, gas liquid chromatography (GC) and mass spectrometry (MS). Harman (1-methyl-β-carboline) was the only β-carboline unequivocally identified in platelet samples with these techniques. Since harman is thought to be biosynthesized by the condensation of tryptamine and acetaldehyde, its formation may be of importance in the metabolism and the pharmacological-toxicological actions of alcohol. © 1979.

引用

页码：157 / 164

页数：8

共 27 条

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AIRAKSINEN MM, 1977, ACTA PHARMACOL TOX, V41, P39

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