ALBUMIN-DEFICIENT RAT MUTANT

被引：281

作者：

NAGASE, S ^{[1
]}

SHIMAMUNE, K ^{[1
]}

机构：

[1] CENT INST EXPTL ANIM,KAWASAKI 221,JAPAN

来源：

SCIENCE | 1979年 / 205卷 / 4406期

关键词：

D O I：

10.1126/science.451621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was -.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin. Copyright © 1979 AAAS.

引用

页码：590 / 591

页数：2

共 8 条

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