ATTENUATION OF HIPPOCAMPAL INHIBITION BY A NMDA (N-METHYL-D-ASPARTATE) RECEPTOR ANTAGONIST

被引：15

作者：

CAPEK, R

ESPLIN, B

机构：

[1] Department of Pharmacology and Therapeutics, McGill University, Montreal

来源：

NEUROSCIENCE LETTERS | 1991年 / 129卷 / 01期

基金：

英国医学研究理事会;

关键词：

HIPPOCAMPAL SLICE; NMDA RECEPTOR; INHIBITORY PATHWAY; DISINHIBITION; APV; AP5;

D O I：

10.1016/0304-3940(91)90741-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the competitive NMDA (N-methyl-D-aspartate) receptor antagonist, APV (2-amino-5-phosphonopentanoate; AP5), were examined in the hippocampal slice preparation. APV (50-100-mu-M) attenuated inhibition of the orthodromically evoked population spikes in the CA1 region produced by a conditioning stimulus to the alveus or to the stratum radiatum. This suggests that NMDA receptors contribute to synaptic activation of the inhibitory interneurons by a single afferent volley.

引用

页码：145 / 148

页数：4

共 25 条

[1]

Alger B.E., 1984, BRAIN SLICES, P381

[2] EFFECT OF PHENCYCLIDINE ON INHIBITION IN THE HIPPOCAMPAL SLICE [J].