A NEW INHIBITOR OF PROTEIN-KINASE-C, RK-1409B (4'-DEMETHYLAMINO-4'-HYDROXY-3'-EPISTAUROSPORINE)

被引：20

作者：

KOSHINO, H

OSADA, H

AMANO, S

ONOSE, R

ISONO, K

机构：

[1] Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research, Wako

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期

关键词：

D O I：

10.7164/antibiotics.45.1428

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

RK-1409B, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated on the basis of spectroscopic analyses. RK-1409B inhibited protein kinase C in vitro and the morphological change of a human chronic leukemia cell line, K-562, induced by phorbol 12,13-dibutyrate with IC50 value of 0.4 mum.

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页码：1428 / 1432

页数：5

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