SCATTER FACTOR FROM HUMAN EMBRYONIC LUNG FIBROBLASTS IS PROBABLY IDENTICAL TO HEPATOCYTE GROWTH-FACTOR

被引：82

作者：

KONISHI, T

TAKEHARA, T

TSUJI, T

OHSATO, K

MATSUMOTO, K

NAKAMURA, T

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT SURG 1,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(05)81131-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human embryonic lung fibroblasts (MRC5) produced scatter factor which enhanced motility of Madin-Darby canine kidney (MDCK) epithelial cells and a factor which stimulates DNA synthesis of adult rat hepatocytes in primary culture. These activities were both completely neutralized by antibody against human hepatocyte growth factor (HGF). Human recombinant HGF induced a marked scattering of MDCK cells. Moreover, MRC5 cells highly expressed 6kb mRNA which hybridized with HGF cDNA probe and scatter factor cDNA cloned from the MRC5 cDNA library had the same sequence as that of HGF cDNA from human leukocytes. These results indicate that HGF possesses scatter factor activity and the scatter factor derived from the MRC5 cells is probably identical to HGF. © 1991 Academic Press, Inc.

引用

页码：765 / 773

页数：9

共 32 条

[1] ASAMI O, 1991, J BIOCHEM-TOKYO, V109, P8
[2] IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT
BOTTARO, DP
RUBIN, JS
FALETTO, DL
CHAN, AML
KMIECIK, TE
VANDEWOUDE, GF
AARONSON, SA
[J]. SCIENCE, 1991, 251 (4995) : 802 - 804
[3] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[4] FURLONG RA, 1991, IN PRESS J CELL SCI
[5] HEPATOCYTES AND SCATTER FACTOR
GHERARDI, E
STOKER, M
[J]. NATURE, 1990, 346 (6281) : 228 - 228
[6] PURIFICATION OF SCATTER FACTOR, A FIBROBLAST-DERIVED BASIC-PROTEIN THAT MODULATES EPITHELIAL INTERACTIONS AND MOVEMENT
GHERARDI, E
GRAY, J
STOKER, M
PERRYMAN, M
FURLONG, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) : 5844 - 5848
[7] PURIFICATION AND PARTIAL CHARACTERIZATION OF HEPATOCYTE GROWTH-FACTOR FROM PLASMA OF A PATIENT WITH FULMINANT HEPATIC-FAILURE
GOHDA, E
TSUBOUCHI, H
NAKAYAMA, H
HIRONO, S
SAKIYAMA, O
TAKAHASHI, K
MIYAZAKI, H
HASHIMOTO, S
DAIKUHARA, Y
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (02) : 414 - 419
[8] IDENTITY OF A TUMOR CYTOTOXIC FACTOR FROM HUMAN FIBROBLASTS AND HEPATOCYTE GROWTH-FACTOR
HIGASHIO, K
SHIMA, N
GOTO, M
ITAGAKI, Y
NAGAO, M
YASUDA, H
MORINAGA, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 170 (01) : 397 - 404
[9] IDENTIFICATION AND CHANGE IN THE RECEPTOR FOR HEPATOCYTE GROWTH-FACTOR IN RAT-LIVER AFTER PARTIAL-HEPATECTOMY OR INDUCED HEPATITIS
HIGUCHI, O
NAKAMURA, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (02) : 599 - 607
[10] HEPATOCYTE GROWTH-FACTOR IS A POTENT MITOGEN FOR CULTURED RABBIT RENAL TUBULAR EPITHELIAL-CELLS
IGAWA, T
KANDA, S
KANETAKE, H
SAITOH, Y
ICHIHARA, A
TOMITA, Y
NAKAMURA, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (02) : 831 - 838

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