SYNTHESIS OF 4'-CYANOTHYMIDINE AND ANALOGS AS POTENT INHIBITORS OF HIV

被引：87

作者：

OYANG, C ^{[1
]}

WU, HY ^{[1
]}

FRASERSMITH, EB ^{[1
]}

WALKER, KAM ^{[1
]}

机构：

[1] SYNTEX INC,3401 HILLVIEW AVE,PALO ALTO,CA 94304

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)77667-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4'-Cyanothymidine inhibits HIV in A301 (Alex) cells with an IC50 of 0.002-mu-M. The uridine and cytidine analogs show similar potencies.

引用

页码：37 / 40

页数：4

共 17 条

[1] RETROVIRUS-INDUCED ACQUIRED IMMUNODEFICIENCIES [J].

BENDINELLI, M ;

MATTEUCCI, D ;

FRIEDMAN, H .

ADVANCES IN CANCER RESEARCH, 1985, 45 :125-181

[2] SYNTHETIC STUDIES TOWARDS (-)-CARBA-3'-DEOXY-3'-FLUOROTHYMIDINE [J].

BERES, J ;

SAGI, G ;

BAITZGACS, E ;

TOMOSKOZI, I ;

GRUBER, L ;

OTVOS, L .

TETRAHEDRON, 1989, 45 (19) :6271-6280

[3]

BUCK JS, 1943, ORG SYNTH, P622

[4]

CHIRIGOS M A, 1965, Cancer Chemother Rep, V45, P29

[5] ANTI-HIV-1 ACTIVITY OF 2',3'-DIDEOXYNUCLEOSIDE ANALOGS - STRUCTURE-ACTIVITY RELATIONSHIP [J].

DECLERCQ, E ;

VANAERSCHOT, A ;

HERDEWIJN, P ;

BABA, M ;

PAUWELS, R ;

BALZARINI, J .

NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6) :659-671

[6] NEW ACQUISITIONS IN THE DEVELOPMENT OF ANTI-HIV AGENTS [J].

DECLERCQ, E .

ANTIVIRAL RESEARCH, 1989, 12 (01) :1-19

[7] 4-(1,2,4-TRIAZOL-1-YL) AND 4-(3-NITRO-1,2,4-TRIAZOL-1-YL)-1-(BETA-D-2,3,5-TRI-O-ACETYLARABINOFURANOSYL)PYRIMIDIN-2(1H)-ONES - VALUABLE INTERMEDIATES IN THE SYNTHESIS OF DERIVATIVES OF "1-(BETA-D-ARABINOFURANOSYL)CYTOSINE (ARA-C) [J].

DIVAKAR, KJ ;

REESE, CB .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (05) :1171-1176

[8]

GLAXO, 1990, Patent No. 345076

[9] 4'-SUBSTITUTED NUCLEOSIDES .5. HYDROXYMETHYLATION OF NUCLEOSIDE 5'-ALDEHYDES [J].

JONES, GH ;

TANIGUCHI, M ;

TEGG, D ;

MOFFATT, JG .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (08) :1309-1317

[10]

MAAG H, 1990, Patent No. 371366

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