INFLUENCE OF VANADATE ON CALCIUM FLUXES AND NET MOVEMENT OF CALCIUM IN INTACT SQUID AXONS

被引：10

作者：

BAKER, PF

SINGH, R

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1981年 / 646卷 / 03期

关键词：

D O I：

10.1016/0005-2736(81)90314-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular vanadate at a concentration of 100 .mu.M inhibits the uncoupled efflux of Ca2+ from intact axons but has little effect on the exchange fluxes and on the Ca2+-dependent Na+ efflux. External vanadate has no effect on the Ca2+ efflux. Intracellular vanadate inhibits the Ca2+ efflux in the presence of external Na+ and Ca2+, suggesting that the uncoupled efflux is operative under physiological conditions. Measurements of the net movements of Ca2+ under near physiological conditions confirmed this conclusion.

引用

页码：450 / 456

页数：7

共 14 条

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