INHIBITION OF HIV-INFECTION BY FLAVANOIDS

被引：83

作者：

MAHMOOD, N

PIZZA, C

AQUINO, R

DETOMMASI, N

PIACENTE, S

COLMAN, S

BURKE, A

HAY, AJ

机构：

[1] UNIV NAPOLI,DIPARTIMENTO CHIM SOSTANZE NAT,NAPLES,ITALY

[2] NATL INST MED RES,LONDON,ENGLAND

来源：

ANTIVIRAL RESEARCH | 1993年 / 22卷 / 2-3期

关键词：

FLAVANOIDS; HIV; GP120-CD4; INTERACTION;

D O I：

10.1016/0166-3542(93)90095-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Of a variety of flavanoids, the flavans were generally more effective than flavones and flavanones in selective inhibition of HIV-1, HIV-2 or SIV infection. Studies of their effects on the binding of sCD4 and antibody to gp120 indicated that the effective compounds interact irreversibly with gp120 to inactivate virus infectivity and block infection.

引用

页码：189 / 199

页数：11

共 23 条

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