EFFECTIVE TUMOR VACCINE GENERATED BY FUSION OF HEPATOMA-CELLS WITH ACTIVATED B-CELLS

被引：143

作者：

GUO, YJ ^{[1
]}

WU, MC ^{[1
]}

CHEN, H ^{[1
]}

WANG, XN ^{[1
]}

LIU, GL ^{[1
]}

LI, GL ^{[1
]}

MA, J ^{[1
]}

SY, MS ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

来源：

SCIENCE | 1994年 / 263卷 / 5146期

关键词：

D O I：

10.1126/science.7507262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fusion of BERH-2 rat hepatocellular carcinoma cells with activated B cells produced hybrid cells that lost their tumorigenicity and became immunogenic. Syngeneic rats injected with BERH-2-B hybrid cells became resistant to challenge with parental BERH-2 cells, and rats with established BERH-2 hepatomas were cured by subsequent injection of BERH-2-B cells. Both CD4+ and CD8+ cells were essential for the induction of protective immunity; however, only CD8+ cells were required for the eradication of BERH-2 tumors. The generation of hybrid tumor cells that elicit antitumor immune responses may be a useful strategy for cancer immunotherapy.

引用

页码：518 / 520

页数：3

共 18 条

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