PERIPHERAL-BLOOD STEM-CELL MOBILIZATION USING HIGH-DOSE CYCLOPHOSPHAMIDE AND G-CSF IN PRETREATED PATIENTS WITH LYMPHOMA

被引：23

作者：

CRAIG, JIO ^{[1
]}

ANTHONY, RS ^{[1
]}

STEWART, A ^{[1
]}

THOMSON, EB ^{[1
]}

GILLON, J ^{[1
]}

PARKER, AC ^{[1
]}

机构：

[1] ROYAL EDINBURGH & ASSOCIATED HOSP,SE SCOTLAND BLOOD TRANSFUS SERV,EDINBURGH EH3 9YW,MIDLOTHIAN,SCOTLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb08675.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral blood stem cell (PBSC) mobilization for autologous transplantation is more difficult in treated patients and those with bone marrow involvement. In 17 pretreated lymphoma patients, cyclophosphamide (4 g/ml) and G-CSF mobilized a median circulating peak of 19 59 CFU-GM/ml on day 12.5. PBSC harvesting commenced when WBC was 1 x 10(9)/l at day 10.5 collected a median of 21.2 x 10(4)/CFU-GM/kg. 13/17 (76%) patients exceeded the 10 X 10((4) CFU-GM/kg threshold for engraftment. The CFU-GM yield was significantly higher in patients whose WBC recovered from 1-5 x 10(9)/1 in less than 3 days and correlated with the maximum WBC pre and post the cyclophosphamide induced nadir. This regime safely mobilized adequate PBSC in the majority of pretreated lymphoma patients.

引用

页码：210 / 212

页数：3

共 12 条

[1]

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