HEPATITIS-C VIRUS - DOES IT PENETRATE THE HEMODIALYSIS MEMBRANE

被引：38

作者：

HUBMANN, R ^{[1
]}

ZAZGORNIK, J ^{[1
]}

GABRIEL, C ^{[1
]}

GARBEIS, B ^{[1
]}

BLAUHUT, B ^{[1
]}

机构：

[1] TRANSFUS SERV UPPER AUSTRIA,LINZ,AUSTRIA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 1995年 / 10卷 / 04期

关键词：

HEPATITIS C; HEMODIALYSIS; TRANSMISSION; INFECTION; PCR (POLYMERASE CHAIN REACTION); DIAGNOSTIC;

D O I：

10.1093/ndt/10.4.541

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Hepatitis C virus (HCV) transmission to haemodialysis patients occurs by a route which remains to be clarified. Most studies show a significant correlation between anti-HCV-seropositivity and the number of blood transfusions or the duration of dialysis respectively. However, even in patients who have not received a blood transfusion the prevalence of HCV infection was significantly higher than in controls. We studied 58 patients on regular haemodialysis using a second-generation enzyme-linked immunosorbent assay (ELISA II) followed by a second-generation recombinant immunosorbent assay (RIBA II) for HCV. For all antibody-positive or indeterminate patients, polymerase chain reaction (PCR) analysis was done using both whole blood and dialysed ultrafiltrate. We were able to show by PCR that no HCV RNA (cell particles) passed through the dialysis membranes.

引用

页码：541 / 542

页数：2

共 9 条

[1] TRANSMISSION OF ANTI-HCV WITHIN THE HOUSEHOLD OF HEMODIALYSIS-PATIENTS [J].