The effects of deleterious mutations on evolution in non-recombining genomes

被引：99

作者：

Kaiser, Vera B. ^{[1
]}

Charlesworth, Brian ^{[1
]}

机构：

[1] Univ Edinburgh, Ashworth Labs, Sch Biol Sci, Inst Evolutionary Biol, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 01期

关键词：

SYNONYMOUS CODON USAGE; BACKGROUND SELECTION; DROSOPHILA-MELANOGASTER; Y-CHROMOSOME; PATTERNS; POLYMORPHISM; FITNESS; MIRANDA; POPULATIONS; DIVERSITY;

D O I：

10.1016/j.tig.2008.10.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Analyzing regions of the Drosophila, genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes progressively less effective in influencing the behaviour of neighbouring sites as the number of closely linked sites on a chromosome increases.

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页码：9 / 12

页数：4

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