SKELETAL UPTAKE OF SIMULTANEOUSLY INGESTED FLUORIDE AND CALCIUM IN RAT

被引：10

作者：

ERICSSON, Y

机构：

[1] Laboratory of Oral Biochemistry, Karolinska Institutet, Stockholm, S-103 64

[2] Department of Cariology, Karolinska Institutet, Stockholm, S-103 64

来源：

CALCIFIED TISSUE RESEARCH | 1969年 / 3卷 / 04期

关键词：

Bone; Calcium; compatibility; Fluoride; Ingestion;

D O I：

10.1007/BF02058676

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Rat experiments with labelled compounds were carried out in order to test the possibilities of simultaneous peroral supply of fluorine (F) and calcium (Ca) in proportions calculated for treatment of certain human osteopenias. F in the form of Na2PO3F and Ca in the form of calcium gluconate (CaGluc) did not interfere with each other's utilisation by the skeleton (femur). A high viscosity produced by adding starch or carboxymethyl cellulose (CMC) to the ingested solution or slurry increased the utilisation of F even when CaGluc was replaced by calcium citrate, which moderately reduced F utilisation. Calcium glycerophosphate strongly reduced F utilisation even in the presence of CMC. The utilisation of F as NaF was strongly reduced by CaGluc, even in the presence of CMC. The tested concentrations of Na2PO3F, NaF or CMC did not influence the skeletal utilisation of Ca as CaGluc. © 1969 Springer-Verlag.

引用

页码：340 / &

共 27 条

[1]

BERNSTEIN DANIEL S., 1963, JOUR CLIN INVEST, V42, P916

[2]

Bjerrum J., 1957, STABILITY CONSTANTS

[3] NEW BONE FORMATION IN OSTEOPOROSIS FOLLOWING TREATMENT WITH SODIUM FLUORIDE [J].