UTERINE-PLACENTAL-FETAL PREPARATION IN SITU ON DOG . INVESTIGATION OF METABOLIZING ACTIVITY AND TISSUE DISTRIBUTION

被引:4
作者
BENZI, G
BERTE, F
CREMA, A
ARRIGONI, E
机构
关键词
Fetal tissue—drug distribution; Perfusion technique—drug administration Metabolic activity; Uterine–placental–fetal preparation—in situ;
D O I
10.1002/jps.2600570627
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The extracorporeal perfusion technique in situ has been used to evaluate the metabolizing activity of the uterine–placental–fetal preparation on the dog. The pregnant uterus isolated from general circulation was supplied with a pump‐oxygenator system. The method was tested studying the metabolic transformation of amino‐pyrine to 4‐aminoantipyrine and N‐acetyl‐4‐aminoantipyrine, and evaluating their distribution in fetal tissues. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company
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页码:1031 / &
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