ROLES OF GONADAL STEROID-HORMONES IN PSYCHIATRIC DEPRESSION IN MEN AND WOMEN

被引：91

作者：

VOGEL, W ^{[1
]}

KLAIBER, EL ^{[1
]}

BROVERMAN, DM ^{[1
]}

机构：

[1] WORCESTER FDN EXPTL BIOL,SHREWSBURY,MA 01545

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY | 1978年 / 2卷 / 04期

关键词：

Depression; estrogen; testosterone;

D O I：

10.1016/0364-7722(78)90107-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. Depressed men and women who fail to respond to conventional antidepressant treatment show significant alleviation of depressive symptoms when treated with high doses of gonadal steroids (conjugated oral estrogen in women; mesterolone in men). 2. 2. Depression in men is accompanied by a high production of estradiol; and depression in women is accompanied by higher production of testosterone. Whether these findings are related to the therapeutic effects of gonadal hormones upon depression are unknown. © 1978.

引用

页码：487 / 503

页数：17

共 27 条

[1]

ABRAHAM GE, 1970, IMMUNOLOGIC METHODS, P87

[2]

Baird D T, 1969, Recent Prog Horm Res, V25, P611

[3] INTERACTIONS BETWEEN ESTROGENS AND CATECHOL AMINES .3. STUDIES ON METHYLATION OF CATECHOL ESTROGENS, CATECHOL AMINES AND OTHER CATECHOLS BY CATECHOL-O-METHYLTRANSFERASE OF HUMAN LIVER [J].