THE METABOLIC ANATOMY OF PARKINSONS-DISEASE - COMPLEMENTARY [F-18] FLUORODEOXYGLUCOSE AND [F-18] FLUORODOPA POSITRON EMISSION TOMOGRAPHIC STUDIES

被引：189

作者：

EIDELBERG, D

MOELLER, JR

DHAWAN, V

SIDTIS, JJ

GINOS, JZ

STROTHER, SC

CEDARBAUM, J

GREENE, P

FAHN, S

ROTTENBERG, DA

机构：

[1] Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York

[2] Cornell University Medical College, New York, New York

[3] Department of Neurology, North Shore University Hospital, Manhasset, New York

[4] Department of Neurology, Burke Rehabilitation Hospital, White Plains, New York

[5] Department of Neurology, Columbia University College of Physicians and Surgeons, Neurological Institute, New York, New York

[6] Department of Psychiatry, Columbia University College of Physicians

[7] PET Imaging Service, Veterans Administration Medical Center, Minneapolis, Minnesota, One Veterans Drive

[8] Department of Neurology, University of Minnesota, Minneapolis, Minnesota

[9] Surgeons, Psychiatric Institute, New York, New York

来源：

MOVEMENT DISORDERS | 1990年 / 5卷 / 03期

关键词：

Metabolic anatomy; Parkinson's disease; Positron emission tomography; [!sup]18[!/sup]F]Fluorodeoxyglucose; [!sup]18[!/sup]F]Fluorodopa;

D O I：

10.1002/mds.870050304

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the metabolic anatomy of typical Parkinson's disease (PD) using [18F]fluorodeoxyglucose (FDG) and [18F]fluorodopa (FDOPA) and positron emission tomography (PET). Fourteen PD patients (mean age 49 years) had FDG/PET scans, of which 11 were scanned with both FDOPA and FDG. After the injection of FDOPA, brain uptake and arterial plasma radioactivity were monitored for 2 h. Striatal FDOPA uptake was analyzed with regard to a two‐compartment model, and target‐to‐background ratios (TBRs) and TBR‐versus‐time slopes were also calculated. Regional patterns of metabolic covariation were extracted from FDG/PET data using the Scaled Subprofile Model (SSM). SSM pattern weights, FDOPA uptake constants (Ki), TBRs, and TBR slopes were correlated with clinical measures for bradykinesia, rigidity, tremor, gait disturbance, left‐right asymmetry, dementia, and overall disease severity. In PD patients, rate constants for FDOPA uptake correlated with individual measures of bradykinesia (p = 0.001) and gait disability (p < 0.05). SSM analysis revealed a distinct pattern of regional metabolic asymmetries, which correlated with motor asymmetries (p < 0.001) and left‐right differences in Ki (p < 0.01). Our data suggest that in PD patients, FDG/PET and FDOPA/PET may provide unique and complementary information about underlying disease processes. Copyright © 1990 Movement Disorder Society

引用

页码：203 / 213

页数：11

共 53 条

[1] Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F, Brain dopamine and the syndromes of Parkinson and Huntington: clinical, morphological and neurochemical correlations, J Neurol Sci, 20, pp. 415-455, (1973)
[2] Wooten GF, Collins RC, Metabolic effects of unilateral lesions of the substantia nigra, J Neurosci, 1, pp. 285-291, (1981)
[3] Porrino LJ, Burns RS, Crane AM, Et al., Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by MPTP in the primate, Life Sci, 40, pp. 1657-1664, (1987)
[4] Porrino LJ, Burns RS, Crane AM, Et al., Local cerebral metabolic effects of L‐dopa therapy in 1‐methyl‐4‐phenyl‐1,2,3,6 tetrahydropyridine‐induced parkinsonism in monkeys, Proc Natl Acad Sci, 84, pp. 5995-5999, (1987)
[5] Wolfson LI, Leenders KL, Brown LL, Jones T, Alterations of regional cerebral flow of oxygen metabolism in Parkinson's disease, Neurology, 35, pp. 1399-1405, (1985)
[6] Perlmutter JS, Raichle ME, Regional blood flow in hemiparkinsonism, Neurology, 35, pp. 1127-1134, (1985)
[7] Rougemont D, Baron JC, Collard P, Et al., Local cerebral glucose utilization in treated and untreated patients with Parkinson's disease, J Neurol Neurosurg Psychiatry, 47, pp. 824-830, (1984)
[8] Kuhl DE, Metter EJ, Riege WH, Patterns of local cerebral glucose utilization determined in Parkinson's disease by the [<sup>18</sup>F]fluorodeoxyglucose method, Ann Neurol, 15, pp. 419-424, (1984)
[9] Martin WRW, Beckman JH, Caine DB, Et al., Cerebral glucose metabolism in Parkinson's disease, Can J Neurol Sci, 11, pp. 169-173, (1984)
[10] Garnett ES, Firnau G, Nahmias C, Chirakal R, Striatal dopamine metabolism in living monkeys examined by positron emission tomography, Brain Res, 280, pp. 169-171, (1983)

← 1 2 3 4 5 6 →