THE SYNTHESIS OF RING-EXPANDED ANALOGS OF XANTHINE CONTAINING THE IMIDAZO[4,5-E][1,4]DIAZEPINE RING-SYSTEM

被引：24

作者：

HOSMANE, RS

BHAN, A

机构：

[1] Laboratory for Chemical Dynamics, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1002/jhet.5570270759

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 4,5,7,8-tetrahydro-6H-imidazo[4,5-e][1,4]diazepine-5,8-dione and its several 1- and 3-alkyl (aralkyl) derivatives 2 has been reported. Mechanistic explorations of the final synthetic step as well as structural confirmation of a final product 2d by single-crystal X-ray diffraction analyses have also been presented.

引用

页码：2189 / 2196

页数：8

共 29 条

[1] STRUCTURE OF A REARRANGEMENT PRODUCT - 1-METHYL-3-(5-AMINO-1-BENZYLIMIDAZOL-4-YL)-1,2,4-TRIAZOLE, C13H14N6 [J].

AFSHAR, C ;

BERMAN, HM ;

SAWZIK, P ;

LESSINGER, L ;

LIM, BB ;

HOSMANE, RS .

JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1987, 17 (04) :533-543

[2]

Agarwal RP, 1978, CHEM BIOL NUCLEOSIDE, P159

[3] The constitution of purine nucleosides Part X A new synthesis of xanthine and attempted syntheses of xanthine glucosides from glyoxalines [J].

Allsebrook, WE ;

Gulland, JM ;

Story, LF .

JOURNAL OF THE CHEMICAL SOCIETY, 1942, :232-236

[4]

BOYD GV, 1984, COMPREHENSIVE HETERO, V6, P203

[5] IMIDAZO[4,5-E][1,3]DIAZEPINE-4,6-DIONE - A NOVEL XANTHINE ANALOG [J].

BRIDSON, PK ;

LAMBERT, SJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (01) :173-175

[6] CYCLIC HOMOLOGS OF XANTHINES .1. IMIDAZO[4,5-E][1,4]DIAZEPINE-5,8-DIONES [J].

BRIDSON, PK ;

WEIRICH, TP .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (04) :1179-1182

[7] THE REACTION OF 5-AMINOIMIDAZOLE-4-CARBOHYDRAZIDES WITH ORTHO-ESTERS [J].

BRIDSON, PK ;

DAVIS, RA ;

RENNER, LS .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (03) :753-755

[8] TOTAL SYNTHESIS OF (8R)-3-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)-3,6,7,8-TETRAHYDROIMIDAZO[4,5-D][1,3]DIAZEPIN-8-OL (PENTOSTATIN), THE POTENT INHIBITOR OF ADENOSINE-DEAMINASE [J].

CHAN, E ;

PUTT, SR ;

SHOWALTER, HDH ;

BAKER, DC .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (18) :3457-3464

[9] 2-BENZAZEPINES .8. ZEROVALENT NICKEL MEDIATED BIARYL SYNTHESIS OF AN ANXIOLYTIC PYRIMIDO[5,4-D][2]BENZAZEPINE [J].

COFFEN, DL ;

SCHAER, B ;

BIZZARRO, FT ;

CHEUNG, JB .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (02) :296-300

[10]

FILLER R, 1977, ADV HETEROCYCL CHEM, V21, P175

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