CANINE-DISTEMPER VIRUS LOCALIZED IN BONE-CELLS OF PATIENTS WITH PAGETS-DISEASE

被引：99

作者：

GORDON, MT ^{[1
]}

ANDERSON, DC ^{[1
]}

SHARPE, PT ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CELL & STRUCT BIOL,BONE DIS RES CTR,STOPFORD BLDG,MANCHESTER M13 9PT,LANCS,ENGLAND

来源：

BONE | 1991年 / 12卷 / 03期

基金：

英国惠康基金;

关键词：

PAGETS DISEASE; CANINE DISTEMPER VIRUS; OSTEOCLAST;

D O I：

10.1016/8756-3282(91)90042-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The technique of in situ hybridisation was applied using radioactively labelled riboprobes to examine for the presence of canine distemper (CDV) and measles (MV) RNA in Paget's disease of bone. The results indicate that in 41% of Paget's patients, CDV RNA could be detected in osteoclasts, osteoblasts, and osteocytes, but not in controls. In contrast, RNA to the measles virus was not detected. We suggest that CDV may in some cases play a role in the aetiology of Paget's disease.

引用

页码：195 / 201

页数：7

共 31 条

[1]

ANDERSON DC, 1989, ADV ENDOCRINOLOGY, V6, P156

[2]

ANGERER LM, 1987, IN SITU HYBRIDIZATIO, P42

[3]

BARKER DJ, 1981, BONE DIS REL RES, V3, P231

[4] PAGETS-DISEASE OF BONE IN 14 BRITISH TOWNS [J].