COMPARISON OF 3 PROTRACTED ANTIEMETIC REGIMENS FOR THE CONTROL OF DELAYED EMESIS IN CISPLATIN-TREATED PATIENTS

被引：28

作者：

MORENO, I

ROSELL, R

ABAD, A

BARNADAS, A

CARLES, J

RIBELLES, N

SOLANO, V

FONT, A

机构：

[1] UNIV BARCELONA,HOSP GERMANS TRIAS I PUJOL,MED ONCOL UNIT,BOX 72,E-08916 BARCELONA,SPAIN

[2] HOSP TERRASA,MED ONCOL UNIT,BARCELONA,SPAIN

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 8-9期

关键词：

D O I：

10.1016/0959-8049(92)90515-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antiemetic activity of three protracted regimens for the control of cisplatin-evoked delayed emesis was explored. 63 patients were randomly assigned to receive one of three protracted antiemetic schedules over 4 days. Group C patients received dexamethasone 8 mg twice daily on days 2 and 3, then 4 mg twice daily on days 4 and 5; in group B, alizapride 2.5 mg/kg four times daily on days 2-5 plus dexamethasone as in group C was administered; and in group A, metoclopramide 0.5 mg/kg four times daily on days 2-5 plus dexamethasone was given at the same dose-schedule as in groups C and B. Complete protection from delayed vomiting was achieved in 44% of group C, 30% of B and 70% of group A (P = 0.02). Mild side-effects were noted in all three groups. A higher complete protection for delayed emesis was obtained in metoclopramide-dexamethasone-treated patients. Neither of the regimens used in the protection of delayed emesis controlled late nausea.

引用

页码：1344 / 1347

页数：4

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