CLEARANCE OF TC-99M-DTPA AND EXPERIMENTALLY INCREASED ALVEOLAR SURFACTANT CONTENT

被引:35
作者
BOS, JAH
WOLLMER, P
BAKKER, W
HANNAPPEL, E
LACHMANN, B
机构
[1] UNIV LUND,DEPT CLIN PHYSIOL,LASARETTET,S-22185 LUND,SWEDEN
[2] ERASMUS UNIV,DEPT ANAESTHESIOL,3000 DR ROTTERDAM,NETHERLANDS
[3] ERASMUS UNIV,DEPT NUCL MED,3000 DR ROTTERDAM,NETHERLANDS
[4] UNIV ERLANGEN NURNBERG,INST BIOCHEM,W-8520 ERLANGEN,GERMANY
关键词
AMBROXOL; MECHANICAL VENTILATION; PULMONARY SURFACTANTS; RABBIT; RADIONUCLIDE IMAGING;
D O I
10.1152/jappl.1992.72.4.1413
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We measured clearance of Tc-99m-labeled diethylenetriamine pentaacetic acid (Tc-99m-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and another group of animals was treated with tracheal instillation of natural surfactant. A group of untreated control animals and animals treated with instillation of saline were also studied. Clearance was measured during standard conditions of mechanical ventilation and during ventilation with large tidal volumes. In ambroxol- and surfactant-treated groups, clearance rate was reduced compared with untreated control animals. In contrast, clearance rate increased after saline instillation. The differences were observed at both modes of ventilation. The findings indicate that the pulmonary surfactant system is a rate-limiting factor for the clearance of Tc-99m-DTPA and that the volume dependence of clearance is not explained by stretching of the alveolar wall only.
引用
收藏
页码:1413 / 1417
页数:5
相关论文
共 28 条
[1]   PULMONARY CLEARANCE OF RADIOTRACERS AFTER POSITIVE END-EXPIRATORY PRESSURE OR ACUTE LUNG INJURY [J].
BARROWCLIFFE, MP ;
ZANELLI, GD ;
JONES, JG .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (01) :288-294
[2]  
BOS JAH, 1992, NEW ASPECTS RESPIRAT, P194
[3]   RELATIONSHIP OF END-EXPIRATORY PRESSURE, LUNG-VOLUME, AND TC-99M-DTPA CLEARANCE [J].
COOPER, JA ;
VANDERZEE, H ;
LINE, BR ;
MALIK, AB .
JOURNAL OF APPLIED PHYSIOLOGY, 1987, 63 (04) :1586-1590
[4]  
DAHLBACK M, 1989, J AEROSOL MED, V2, P339
[5]  
EFFROS RM, 1983, AM REV RESPIR DIS, V127, pS59
[6]  
EFFROS RM, 1991, LUNG SCI F, P1163
[7]  
Elemer G, 1983, Curr Probl Clin Biochem, V13, P47
[8]  
Elemer G, 1983, Prax Klin Pneumol, V37 Suppl 1, P723
[9]   PULMONARY CLEARANCE OF INHALED TC-99M-DTPA - EFFECTS OF SURFACTANT DEPLETION BY LUNG LAVAGE [J].
EVANDER, E ;
WOLLMER, P ;
JONSON, B ;
LACHMANN, B .
JOURNAL OF APPLIED PHYSIOLOGY, 1987, 62 (04) :1611-1614
[10]   PULMONARY CLEARANCE OF INHALED TC-99M-DTPA - EFFECT OF THE DETERGENT DIOCTYL SODIUM SULFOSUCCINATE IN AEROSOL [J].
EVANDER, E ;
WOLLMER, P ;
JONSON, B .
CLINICAL PHYSIOLOGY, 1988, 8 (02) :105-111