STEREOSELECTIVITY IN THE PETERSON REACTION - APPLICATION TO THE SYNTHESIS OF BRL-49467

被引:9
作者
BELL, D [1 ]
CROWE, EA [1 ]
DIXON, NJ [1 ]
GEEN, GR [1 ]
MANN, IS [1 ]
SHIPTON, MR [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)89692-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The E:Z selectivity in the introduction of the tri-substituted double bond in BRL 49467 could be controlled by the choice of base and silyl group used in a Peterson olefination reaction. The method allowing optimum E-selectivity was developed such that it could be scaled up to 100mmol.
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页码:6643 / 6652
页数:10
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