STEREOSELECTIVITY IN THE PETERSON REACTION - APPLICATION TO THE SYNTHESIS OF BRL-49467

被引：9

作者：

BELL, D ^{[1
]}

CROWE, EA ^{[1
]}

DIXON, NJ ^{[1
]}

GEEN, GR ^{[1
]}

MANN, IS ^{[1
]}

SHIPTON, MR ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

TETRAHEDRON | 1994年 / 50卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(01)89692-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The E:Z selectivity in the introduction of the tri-substituted double bond in BRL 49467 could be controlled by the choice of base and silyl group used in a Peterson olefination reaction. The method allowing optimum E-selectivity was developed such that it could be scaled up to 100mmol.

引用

页码：6643 / 6652

页数：10

共 25 条

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