MEGALOMICIN A NEW MACROLIDE ANTIBIOTIC COMPLEX PRODUCED BY MICROMONOSPORA

被引：39

作者：

WEINSTEIN, MJ

WAGMAN, GH

MARQUEZ, JA

TESTA, RT

ODEN, E

WAITZ, JA

机构：

[1] Department of Microbiology, Schering Corporation, New Jersy, Bloomfield

来源：

JOURNAL OF ANTIBIOTICS | 1969年 / 22卷 / 06期

关键词：

D O I：

10.7164/antibiotics.22.253

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new macrolide antibiotic complex has been isolated from fermentation broths of two strains of a newspecies of Micromonospora, M. megalomicea sp. n. The antibiotic complex has been differentiated from other known macrolides and methods for its production, isolation and separation of components have been devised. Like other macrolides, it is primarily active against gram-positive bacteria and is more active at an alkaline pH. Of the four knowncomponents, megalomicin A has been studied most extensively. It has activity equal to or slightly less than that of erythromycin both in vitro and in vivo. In dogs dosed orally, it is better tolerated and gives higher peak serum levels with a muchgreater duration than erythromycin. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：253 / +

页数：1