SOME ISOINDOLO-FUSED HETEROCYCLIC-SYSTEMS BY CYCLODEHYDRATION OF N-ARYLALKYL-3-HYDROXYPHTHALIMIDINES

被引：28

作者：

HITCHINGS, GJ ^{[1
]}

HELLIWELL, M ^{[1
]}

VERNON, JM ^{[1
]}

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 01期

关键词：

D O I：

10.1039/p19900000083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

α-Hydroxy lactams formed by reduction or Grignard addition to appropriately N-substituted phthalimides (1a-d) undergo acid-catalysed cyclodehydration to derivatives of the isoindolo-fused heterocyclic systems (6)-(10). Ring closures to the naphthalene 2- or 8-position are observed to occur with N-1-naphthylalkyl substituents, the latter proved by an X-ray crystal structure determination of 13b-phenyl-7H-benz[de]isoindolo[1,2-a]isoquinolin- 9(13H)-one (9b).

引用

页码：83 / 87

页数：5

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