A ROLE FOR NA+/H+ EXCHANGE IN CONTRACTION OF GUINEA-PIG AIRWAYS BY ENDOTHELIN-1 INVITRO

被引：8

作者：

BATTISTINI, B

FILEP, JG

CRAGOE, EJ

FOURNIER, A

SIROIS, P

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT PHARMACOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

[2] INST NATL RECH SANTE,MONTREAL,QUEBEC,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 175卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(91)91605-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1-induced contractions of guinea pig tracheal and bronchial strips were dose-dependently attenuated by the amiloride analogues 5-(N-ethyl-N-isopropyl)amiloride (EIPA, 1-10 μM) and 5-(N,N-hexamethylene)amiloride (HMA, 1-10 μM). The calculated Ki values for EIPA and HMA were 0.11 ± 0.02 μM and 0.06 ± 0.02 μM in the trachea, and 0.28 ± 0.11 μM and 0.70 ± 0.25 μM in the bronchus, respectively. These values are in the same order of magnitude as those reported for inhibition of the Na+/H+ exchange in cells. Amiloride (1-10 μM) was ineffective. These data suggest that activation of the Na+/H+ exchange by ET-1 may be involved in mediating its myotropic action in guinea pig airway smooth muscle. © 1991.

引用

页码：583 / 588

页数：6

共 16 条

[1] POTENT THROMBOXANE-MEDIATED INVITRO BRONCHOCONSTRICTOR EFFECT OF ENDOTHELIN IN THE GUINEA-PIG [J].